Appendicular lean mass index changes in patients with Duchenne muscular dystrophy and Becker muscular dystrophy.

ABSTRACT:

Introduction

Mutations in the 79 exons of the dystrophin gene result in muscle wasting and weakness of varying clinical severity, ranging from severe/typical Duchenne muscular dystrophy (DMD) to intermediate DMD and mild Becker muscular dystrophy (BMD), depending on the frameshift of the mutation. We previously reported that males with DMD have progressively declining appendicular lean mass (ALM) and ALM index (ALMI) with age and worsening functional motor ability compared with healthy controls. These indices have not been studied in patients with intermediate DMD and BMD phenotypes and across DMD genotypes. In this study, we compared age-related trajectories of ALM and ALMI of patients who had (1) BMD without functional mobility deficits with patients who had DMD at different stag

SUBMITTER: Wong BL 

PROVIDER: S-EPMC10751441 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature