Non-steroidal anti-inflammatory drugs for treatment of cancer cachexia: A systematic review.

ABSTRACT: Cancer cachexia (CC) is a multifactorial syndrome driven by inflammation, defined by ongoing loss of skeletal muscle mass (with or without loss of fat mass) that cannot be fully reversed by conventional nutritional support. CC leads to progressive functional impairment, with its clinical management complicated and limited therapeutic options available. The objective of this review was to assess the efficacy and safety of non-steroidal anti-inflammatory drugs (NSAIDs) on patient-centred outcomes in patients with CC. In 2013, two systematic reviews concluded that there was insufficient evidence to recommend NSAIDs for clinical management of CC outside of clinical trials. However, clinical trials of multi-component CC interventions have included NSAIDs as an intervention component, so an up-t

SUBMITTER: Bowers M 

PROVIDER: S-EPMC10751445 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature