Gastric inhibitory polypeptide receptor antagonism suppresses intramuscular adipose tissue accumulation and ameliorates sarcopenia.

ABSTRACT:

Background

Intramuscular adipose tissue (IMAT) formation derived from muscle fibro-adipogenic progenitors (FAPs) has been recognized as a pathological feature of sarcopenia. This study aimed to explore whether genetic and pharmacological gastric inhibitory polypeptide (GIP) receptor antagonism suppresses IMAT accumulation and ameliorates sarcopenia in mice.

Methods

Whole body composition, grip strength, skeletal muscle weight, tibialis anterior (TA) muscle fibre cross-sectional area (CSA) and TA muscle IMAT area were measured in young and aged male C57BL/6 strain GIP receptor (Gipr)-knockout (Gipr^-/- ) and wild-type (Gipr^+/+ ) mice. FAPs isolated from lower limb muscles of 12-week-old Gipr^+/+ mice were cultured with GIP, and their differentia

SUBMITTER: Takahashi Y 

PROVIDER: S-EPMC10751449 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature