The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas.

ABSTRACT:

Background

Cancer-associated fibroblasts (CAFs), integral to the tumour microenvironment, are pivotal in cancer progression, exhibiting either pro-tumourigenic or anti-tumourigenic functions. Their inherent phenotypic and functional diversity allows for the subdivision of CAFs into various subpopulations. While several classification systems have been suggested for different cancer types, a unified molecular classification of CAFs on a single-cell pan-cancer scale has yet to be established.

Methods

We employed a comprehensive single-cell transcriptomic atlas encompassing 12 solid tumour types. Our objective was to establish a novel molecular classification and to elucidate the evolutionary trajectories of CAFs. We investigated the functional profiles of each CAF subtype usin

SUBMITTER: Chen B 

PROVIDER: S-EPMC10751516 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature