Association Between Serum Glycated Hemoglobin Levels at Early Gestation and the Risk of Subsequent Pregnancy Loss in Pregnant Women Without Diabetes Mellitus: Prospective Cohort Study.

ABSTRACT:

Background

As a severe morbidity during pregnancy, the etiology of spontaneous pregnancy loss (SPL) remains largely unknown. Serum glycated hemoglobin (HbA_1c) level is an established predictor of SPL risk among women with diabetes, but little is known about whether such an association exists among pregnant women without diabetes when glycemic levels are within the normal range.

Objective

This study aimed to quantify the association between maternal HbA_1c levels in early pregnancy and subsequent SPL risk in a cohort of pregnant women without diabetes.

Methods

This prospective cohort study involved 10,773 pregnant women without diabetes enrolled at their first antenatal care visit at a hospital's early pregnancy clinic from March 2016 to December 2

SUBMITTER: Chen X 

PROVIDER: S-EPMC10751628 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature