Hypoxia induced cell dormancy of salivary adenoid cystic carcinoma through miR-922/DEC2 axis.

ABSTRACT:

Background

Hypoxia has been shown to induce cancer cells to become dormant meanwhile these cells inclined to disseminate and eventually cause metastasis. However, the molecular mechanism is still elusive. The purpose is to explore whether dormancy-associated microRNAs (DmiRs) get involved in hypoxia-induced cell dormancy of salivary adenoid cystic carcinoma (SACC).

Material and methods

This study performed multi-perspective investigation of the biological effects of miR-922/DEC2 on SACC based on clinical samples, 2D and 3D in vitro model and nude mice in vivo model, based on our previous study of overexpression of DEC2 inducing SACC cellular dormancy.

Results

According to the existing microRNA array of SACC tissue, we found that miR-922 was upregulated in SACC tissue

SUBMITTER: Dai L 

PROVIDER: S-EPMC10751830 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature