The Molecular Mechanisms Involved in the Hypertrophic Scars Post-Burn Injury.

ABSTRACT: Scar formation is a normal response to skin injuries. During the scar-remodeling phase, scar tissue is usually replaced with normal, functional tissue. However, after deep burn injuries, the scar tissue may persist and lead to contractures around joints, a condition known as hypertrophic scar tissue. Unfortunately, current treatment options for hypertrophic scars, such as surgery and pressure garments, often fail to prevent their reappearance. One of the primary challenges in treating hypertrophic scars is a lack of knowledge about the molecular mechanisms underlying their formation. In this review, we critically analyze studies that have attempted to uncover the molecular mechanisms behind hypertrophic scar formation after severe burn injuries, as well as clinical trials conducted to trea

SUBMITTER: Pradhan M 

PROVIDER: S-EPMC10751863 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature