Skin epidermal keratinocyte p53 induces food uptake upon UV exposure.

ABSTRACT:

Introduction

The first cells affected by UVB exposure are epidermal keratinocytes, and p53, the genome guardian, is activated in these cells when skin is exposed to UVB. UVB exposure induces appetite, but it remains unclear whether p53 in epidermal keratinocytes plays a role in this appetite stimulation.

Results

Here we found that food intake was increased following chronic daily UVB exposure in a manner that depends on p53 expression in epidermal keratinocytes. p53 conditional knockout in epidermal keratinocytes reduced food intake in mice upon UVB exposure.

Methods

To investigate the effects of p53 activation following UVB exposure, mice behavior was assessed using the staircase, open-field, elevated-plus maze, and conditioned-place preference tests. In addit

SUBMITTER: Parikh S 

PROVIDER: S-EPMC10751925 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature