Exposure to early-life stress impairs weight-loss maintenance success in mice.

ABSTRACT:

Objective

The impact of early-life stress on weight-loss maintenance is unknown.

Methods

Mice underwent neonatal maternal separation (NMS) from 0 to 3 weeks and were weaned onto a high-fat sucrose diet (HFSD) from 3 to 20 weeks. Calorie-restricted weight loss on a low-fat sucrose diet (LFSD) occurred over 2 weeks to induce a 20% loss in body weight, which was maintained for 6 weeks. After weight loss, half of the mice received running wheels, and the other half remained sedentary. Mice were then fed ad libitum on an HFSD or LFSD for 10 weeks and were allowed to regain body weight.

Results

NMS mice had greater weight regain, total body weight, and adiposity compared with naïve mice. During the first week of refeeding, NMS mice had increased food intake and were in a gr

SUBMITTER: Foright RM 

PROVIDER: S-EPMC10751986 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature