Advances in ligand-specific biosensing for structurally similar molecules.

ABSTRACT: The specificity of biological systems makes it possible to develop biosensors targeting specific metabolites, toxins, and pollutants in complex medical or environmental samples without interference from structurally similar compounds. For the last two decades, great efforts have been devoted to creating proteins or nucleic acids with novel properties through synthetic biology strategies. Beyond augmenting biocatalytic activity, expanding target substrate scopes, and enhancing enzymes' enantioselectivity and stability, an increasing research area is the enhancement of molecular specificity for genetically encoded biosensors. Here, we summarize recent advances in the development of highly specific biosensor systems and their essential applications. First, we describe the rational design prin

SUBMITTER: Xi C 

PROVIDER: S-EPMC10751988 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature