CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8⁺ T cell antitumor immunity.

ABSTRACT: Infiltration of regulatory T (Treg) cells, an immunosuppressive population of CD4⁺ T cells, into solid cancers represents a barrier to cancer immunotherapy. Chemokine receptors are critical for Treg cell recruitment and cell-cell interactions in inflamed tissues, including cancer, and thus are an ideal therapeutic target. Here, we show in multiple cancer models that CXCR3⁺ Treg cells were increased in tumors compared with lymphoid tissues, exhibited an activated phenotype, and interacted preferentially with CXCL9-producing BATF3⁺ dendritic cells (DCs). Genetic ablation of CXCR3 in Treg cells disrupted DC1-Treg cell interactions and concomitantly increased DC-CD8⁺ T cell interactions. Mechanistically, CXCR3 ablation in Treg cells increased tumor a

SUBMITTER: Moreno Ayala MA 

PROVIDER: S-EPMC10752240 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature