Basal cortisol levels do not predict adrenal responsiveness in acute decompensated cirrhosis.

ABSTRACT:

Objective

Morning total cortisol (TC) levels have been shown to predict adrenal dysfunction (AD) in the general population, but their utility in cirrhosis is unknown.

Methods

A retrospective cohort study was performed including all noncritically ill patients at our institution between 2011 and 2022 admitted with acute decompensated cirrhosis who underwent standard-dose adrenocorticotropic hormone (ACTH) stimulation testing. Adrenal dysfunction was defined as an increase in TC (delta TC) level <9 µg/dl 60 minutes after ACTH dosing. Spearman correlation was utilized to assess the relationship between binding globulins and cortisol levels. Multivariate regression analysis was performed to determine if basal TC level or common clinical parameters were predictive of AD.

Result

SUBMITTER: Wentworth BJ 

PROVIDER: S-EPMC10752291 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature