Hair and plasma cortisol throughout the first 3 years of development in infant rhesus macaques, Macaca mulatta.

ABSTRACT: Cortisol expression has been demonstrated to have variation across development in rhesus macaques (Macaca mulatta). There exists contradictory evidence for the nature of this change, and age at which it occurs, across biological sample types. Consequently, we lack a cohesive understanding for cortisol concentrations across the development of a major human health translational model. We examined hair cortisol concentrations over the first 3 years of life for 49 mother-reared infant macaques from mixed-sex outdoor units at the California National Primate Research Center. For 48 of these subjects at infancy, 1 year, and 2 years, we obtained plasma cortisol samples for response to a stressor, adjustment to prolonged stress, and response to dexamethasone injection. Hair cortisol concentrations

SUBMITTER: Pritchard AJ 

PROVIDER: S-EPMC10752380 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature