Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice.

ABSTRACT:

Background

Chronic exposure to inorganic arsenic (iAs) has been associated with type 2 diabetes (T2D). However, potential sex divergence and the underlying mechanisms remain understudied. iAs is not metabolized uniformly across species, which is a limitation of typical exposure studies in rodent models. The development of a new "humanized" mouse model overcomes this limitation. In this study, we leveraged this model to study sex differences in the context of iAs exposure.

Objectives

The aim of this study was to determine if males and females exhibit different liver and adipose molecular profiles and metabolic phenotypes in the context of iAs exposure.

Methods

Our study was performed on wild-type (WT) 129S6/SvEvTac and humanized arsenic +3 methyl transferase (human AS3

SUBMITTER: Todero J 

PROVIDER: S-EPMC10752418 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature