Characterization of candidate factors associated with the metastasis and progression of high-grade serous ovarian cancer.

ABSTRACT:

Background

High-grade serous ovarian cancer (HGSOC) is the biggest cause of gynecological cancer-related mortality because of its extremely metastatic nature. This study aimed to explore and evaluate the characteristics of candidate factors associated with the metastasis and progression of HGSOC.

Methods

Transcriptomic data of HGSOC patients' samples collected from primary tumors and matched omental metastatic tumors were obtained from three independent studies in the National Center for Biotechnology Information (NCBI) Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were selected to evaluate the effects on the prognosis and progression of ovarian cancer using data from The Cancer Genome Atlas (TCGA) database. Hub genes' immune landscapes were e

SUBMITTER: Liu H 

PROVIDER: S-EPMC10752471 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature