Differential cellular immune responses against Orientia tsutsugamushi Karp and Gilliam strains following acute infection in mice.

ABSTRACT: Scrub typhus is a leading cause of febrile illness in endemic countries due to infection with Orientia tsutsugamushi (Ot), a seriously understudied intracellular bacterium. Pulmonary involvement associated with vascular parasitism in patients is common and can develop into life threatening interstitial pneumonia. The diverse antigenicity of Ot genotypes and inter-strain differences in genome content are connected to varied virulence and clinical outcomes; however, detailed studies of strain-related pulmonary immune responses in human patients or small animal models of infection are lacking. In this study, we have used two clinically prevalent bacterial strains (Karp and Gilliam) to reveal cellular immune responses in inflamed lungs and potential biomarkers of disease severity. The results

SUBMITTER: Thiriot JD 

PROVIDER: S-EPMC10752558 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature