HLA-DRB1*15:01 and the MERTK Gene Interact to Selectively Influence the Profile of MERTK-Expressing Monocytes in Both Health and MS.

ABSTRACT:

Background and objectives

HLA-DRB1*15:01 (DR15) and MERTK are 2 risk genes for multiple sclerosis (MS). The variant rs7422195 is an expression quantitative trait locus for MERTK in CD14⁺ monocytes; cells with phagocytic and immunomodulatory potential. We aimed to understand how drivers of disease risk and pathogenesis vary with HLA and MERTK genotype and disease activity.

Methods

We investigated how proportions of monocytes vary with HLA and MERTK genotype and disease activity in MS. CD14⁺ monocytes were isolated from patients with MS at relapse (n = 40) and 3 months later (n = 23). Healthy controls (HCs) underwent 2 blood collections 3 months apart. Immunophenotypic profiling of monocytes was performed by flow cytometry. Methylation of 35

SUBMITTER: Binder MD 

PROVIDER: S-EPMC10752576 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature