Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells.

ABSTRACT: The processing of visual information by retinal starburst amacrine cells (SACs) involves transforming excitatory input from bipolar cells (BCs) into directional calcium output. While previous studies have suggested that an asymmetry in the kinetic properties of BCs along the soma-dendritic axes of the postsynaptic cell could enhance directional tuning at the level of individual branches, it remains unclear whether biologically relevant presynaptic kinetics contribute to direction selectivity (DS) when visual stimulation engages the entire dendritic tree. To address this question, we built multicompartmental models of the bipolar-SAC circuit and trained them to boost directional tuning. We report that despite significant dendritic crosstalk and dissimilar directional preferences along the d

SUBMITTER: Gaynes JA 

PROVIDER: S-EPMC10752589 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature