Association of Blood-Based DNA Methylation Markers With Late-Onset Alzheimer Disease: A Potential Diagnostic Approach.

ABSTRACT:

Background and objectives

There is an urgent need to identify novel noninvasive biomarkers for Alzheimer disease (AD) diagnosis. Recent advances in blood-based measurements of phosphorylated tau (pTau) species are promising but still insufficient to address clinical needs. Epigenetics has been shown to be helpful to better understand AD pathogenesis. Epigenetic biomarkers have been successfully implemented in other medical disciplines, such as oncology. The objective of this study was to explore the diagnostic accuracy of a blood-based DNA methylation marker panel as a noninvasive tool to identify patients with late-onset Alzheimer compared with age-matched controls.

Methods

A case-control study was performed. Blood DNA methylation levels at 46 cytosine-guanine sites (21 gen

SUBMITTER: Acha B 

PROVIDER: S-EPMC10752644 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature