Treatment of very elderly glioblastoma patients ≥ 75 years of age: whom to treat.

ABSTRACT:

Purpose

The prognosis of patients ≥ 75 years suffering from glioblastoma is poor. Novel therapies are usually reserved for patients ≤ 70 years. In an aging population, treatment of very elderly patients remains a challenge.

Methods

Between 2010 and 2018, a total of 977 glioblastoma patients were treated at our institution. Of these, 143 patients were ≥ 75 years at diagnosis. Primary procedure was surgical resection or biopsy followed by adjuvant treatment, whenever possible. We retrospectively investigated overall survival (OS) and potential prognostic factors influencing survival, including Karnofsky Performance Status (KPS), surgical therapy, adjuvant therapy as well as MGMT promotor status.

Results

In very elderly patients, median age was 79 years (range: 75-110).

SUBMITTER: Baumgarten P 

PROVIDER: S-EPMC10752837 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature