Testing the effects of photobiomodulation on angiogenesis in a newly established CAM burn wound model.

ABSTRACT: Burn wounds are a common challenge for medical professionals. Current burn wound models hold several limitations, including a lack of comparability due to the heterogeneity of wounds and differences in individual wound healing. Hence, there is a need for reproducible in vivo models. In this study, we established a new burn wound model using the chorioallantoic membrane assay (CAM) as a surrogate model for animal experiments. The new experimental setup was tested by investigating the effects of the auspicious biophysical therapy, photobiomodulation (PBM), on the wound healing of an induced CAM burn wound with a metal stamp. PBM has been shown to positively influence wound healing through vascular proliferative effects and the increased secretion of chemotactic substances. The easily accessi

SUBMITTER: Firouz B 

PROVIDER: S-EPMC10752885 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature