Genomic inbreeding measures applied to a population of mice divergently selected for birth weight environmental variance.

ABSTRACT: This study aimed to compare different inbreeding measures estimated from pedigree and molecular data from two divergent mouse lines selected for environmental birth weight during 26 generations. Furthermore, the performance of different approaches and both molecular and pedigree data sources for estimating Ne were tested in this population. A total of 1,699 individuals were genotyped using a high-density genotyping array. Genomic relationship matrices were used to calculate molecular inbreeding: Nejati-Javaremi (F _NEJ), Li and Horvitz (F _L&H), Van Raden method 1 (F _VR1) and method 2 (F _VR2), and Yang (F _YAN). Inbreeding based on runs of homozygosity (F

SUBMITTER: Ojeda-Marin C 

PROVIDER: S-EPMC10752941 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature