Sputum microbiota and inflammatory subtypes in asthma, COPD, and its overlap.

ABSTRACT:

Background

Airway microbiota in asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) remains unknown.

Objective

This study with ACO-enriched population aimed to clarify airway microbiota in ACO and in mixed granulocytic inflammation, often detected in ACO and chronic airway diseases.

Methods

This is an observational cross-sectional study. Patients with asthma with airflow limitation, ACO, and COPD were enrolled. Blood tests, pulmonary function, exhaled nitric oxide, and sputum tests were conducted. Sputum microbiota was evaluated using the 16S rRNA gene sequencing technique.

Results

A total of 112 patients (13 asthma, 67 ACO, and 32 COPD) were examined. There were no significant differences in α-diversity among the 3 diseases. The relative abundanc

SUBMITTER: Morimoto C 

PROVIDER: S-EPMC10753087 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature