Development of hydrogel-based standards and phantoms for non-linear imaging at depth.

ABSTRACT:

Significance

Rapid advances in medical imaging technology, particularly the development of optical systems with non-linear imaging modalities, are boosting deep tissue imaging. The development of reliable standards and phantoms is critical for validation and optimization of these cutting-edge imaging techniques.

Aim

We aim to design and fabricate flexible, multi-layered hydrogel-based optical standards and evaluate advanced optical imaging techniques at depth.

Approach

Standards were made using a robust double-network hydrogel matrix consisting of agarose and polyacrylamide. The materials generated ranged from single layers to more complex constructs consisting of up to seven layers, with modality-specific markers embedded between the layers.

Results

These stan

SUBMITTER: Haseeb F 

PROVIDER: S-EPMC10753126 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature