A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma.

ABSTRACT:

Background

Overexpression of the transcription factor NR5A1 and constitutive activation of canonical Wnt signalling leading to nuclear translocation of beta-catenin are hallmarks of malignancy in adrenocortical carcinoma (ACC). Based on the analysis of genomic profiles in H295R ACC cells, Mohan et al. (Cancer Res. 2023; 83: 2123-2141) recently suggested that a major determinant driving proliferation and differentiation in malignant ACC is the interaction of NR5A1 and beta-catenin on chromatin to regulate gene expression.

Methods

I reanalyzed the same set of data generated by Mohan et al. and other published data of knockdown-validated NR5A1 and beta-catenin target genes.

Results

Beta-catenin is mainly found in association to canonical T cell factor/lymphoid enh

SUBMITTER: Lalli E 

PROVIDER: S-EPMC10753177 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature