Prenatal Exposure to Severe Stress and Risks of Ischemic Heart Disease and Stroke in Offspring.

ABSTRACT:

Importance

Prenatal stress is associated with increased risks of several cardiovascular risk factors later in life. However, knowledge regarding the role of prenatal stress in the development of ischemic heart disease (IHD) and stroke is very limited.

Objective

To examine prenatal stress, defined as maternal bereavement, and risks of IHD and stroke in the offspring.

Design, setting, and participants

A cohort study was conducted using data from Danish and Swedish registries. Live singleton births during calendar years 1973-2016 in Denmark (followed up until December 31, 2016) and during calendar years 1973-2014 in Sweden (followed up until December 31, 2021) were included in the analysis.

Exposure

Maternal loss of a close family member (partner, older children,

SUBMITTER: Yang F 

PROVIDER: S-EPMC10753395 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature