Variants at the Interleukin 1 Gene Locus and Pericarditis.

ABSTRACT:

Importance

Recurrent pericarditis is a treatment challenge and often a debilitating condition. Drugs inhibiting interleukin 1 cytokines are a promising new treatment option, but their use is based on scarce biological evidence and clinical trials of modest sizes, and the contributions of innate and adaptive immune processes to the pathophysiology are incompletely understood.

Objective

To use human genomics, transcriptomics, and proteomics to shed light on the pathogenesis of pericarditis.

Design, setting, and participants

This was a meta-analysis of genome-wide association studies of pericarditis from 5 countries. Associations were examined between the pericarditis-associated variants and pericarditis subtypes (including recurrent pericarditis) and secondary phenotype

SUBMITTER: Thorolfsdottir RB 

PROVIDER: S-EPMC10753444 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature