Antibiotic treatment duration for culture-negative sepsis in the pediatric intensive care unit.

ABSTRACT:

Objective

Sepsis remains a leading cause of morbidity and mortality in children. There is very limited guidance for sepsis treatment when cultures remain negative. This study sought to determine the effectiveness of short versus long course of antibiotics when treating culture-negative sepsis and assess for subsequent multidrug-resistant organism (MDRO) acquisition.

Design

Retrospective cohort study.

Setting

Quaternary academic children's hospital.

Patients

Pediatric intensive care unit (ICU) patients with culture-negative sepsis receiving a minimum of 72 hours of antibiotics.

Methods

Patients found to have culture-negative sepsis from January 2017 to May 2020 were divided into two groups: short and long course of antibiotics. Various demographic and lab

SUBMITTER: Wehrenberg K 

PROVIDER: S-EPMC10753480 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature