DEK oncoprotein participates in heterochromatin replication via SUMO-dependent nuclear bodies.

ABSTRACT: The correct inheritance of chromatin structure is key for maintaining genome function and cell identity and preventing cellular transformation. DEK, a conserved non-histone chromatin protein, has recognized tumor-promoting properties, its overexpression being associated with poor prognosis in various cancer types. At the cellular level, DEK displays pleiotropic functions, influencing differentiation, apoptosis and stemness, but a characteristic oncogenic mechanism has remained elusive. Here, we report the identification of DEK bodies, focal assemblies of DEK that regularly occur at specific, yet unidentified, sites of heterochromatin replication exclusively in late S-phase. In these bodies, DEK localizes in direct proximity to active replisomes in agreement with a function in the early mat

SUBMITTER: Pierzynska-Mach A 

PROVIDER: S-EPMC10753498 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature