Laser-Pulse-Length Effects in Ultrafast Laser Desorption.

ABSTRACT: Shortening the laser pulse length opens up new opportunities for laser desorption (LD) of molecules, with benefits for mass spectrometry (MS) sampling and ionization. The capability to ablate any material without the need for an absorbing matrix and the decrease of thermal damage and molecular fragmentation has promoted various applications with very different parameters and postionization techniques. However, the key issues of the optimum laser pulse length and intensity to achieve efficient and gentle desorption of molecules for postionization in MS are not resolved, although these parameters determine the costs and complexity of the required laser system. Here, we address this research gap with a systematic study on the effect of the pulse length on the LD of molecules. Keeping all othe

SUBMITTER: Schmidt M 

PROVIDER: S-EPMC10753527 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature