Synthesis of Some New 1,3,4-Oxadiazole Derivatives and Evaluation of Their Anticancer Activity.

ABSTRACT: In this work, some new 2-[(5-((2-acetamidophenoxy)methyl)-1,3,4-oxadiazol-2-yl)thio]acetamide derivatives (4a-4l) were synthesized and studied for their anticancer activity. Twelve new compounds were tested on the A549 human lung cancer cell line, C6 rat glioma cell line, and L929 murine fibroblast cell line. Compounds 4f, 4i, 4k, and 4l (IC₅₀: 1.59-7.48 μM), and especially 4h (IC₅₀: <0.14 μM), exhibited excellent cytotoxic profile on A549 with selectivity. Compounds 4g and 4h showed remarkable antiproliferative activity on the C6 cell line with IC₅₀ values of 8.16 and 13.04 μM, respectively. The compounds with the lowest IC₅₀ value on the A549 cell line (4f, 4h, 4i, 4k, and 4l) were further

SUBMITTER: Yurttas L 

PROVIDER: S-EPMC10753699 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature