Effectiveness of pharmacogenomics on the response and remission of treatment-resistant depression: a meta-analysis of randomised controlled trials.

ABSTRACT:

Background

Pharmacogenomics (PGx) is a promising tool to realise tailored drug therapy for depression.

Aims

To investigate the treatment efficacy of PGx for treatment-resistant depression (TRD) compared with treatment as usual.

Methods

A systematic search was conducted in PubMed, Embase, the Cochrane Library, Web of Science and PsycINFO to identify relevant studies published from inception to 15 April 2023. Two-arm randomised controlled trials (RCTs) exploring the efficacy of PGx-guided versus unguided treatment for TRD were included. The risk of bias in the included studies was evaluated using the Cochrane risk of bias assessment tool. The overall quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) app

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC10753713 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature