Increased fruit intake is associated with reduced risk of depression: evidence from cross-sectional and Mendelian randomization analyses.

ABSTRACT:

Background

The association between dietary patterns and depression has gained significant attention, but the relationship between fruit intake and depression remains unclear. This study aimed to investigate the role of fruit intake in the risk of depression using data from the National Health and Nutrition Examination Survey (NHANES) and Mendelian randomization (MR) analysis, and further explore the causal relationship between them.

Materials and methods

Cross-sectional analysis was conducted using the 2005-2018 NHANES data. Specialized weighted complex survey design analysis software was used for multivariate logistic analysis. Additionally, genetic variants for fruit intake and depression, as well as its related neuroticism traits, from the GWAS were used as instrumental v

SUBMITTER: Yan Z 

PROVIDER: S-EPMC10753833 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature