Causal analysis of the gut microbiota in differentiated thyroid carcinoma: a two-sample Mendelian randomization study.

ABSTRACT: Objective: Numerous studies have highlighted an association between the gut microbiota (GM) and thyroid tumors. Employing Mendelian randomization methodology, we seek to elucidate the causal link between the gut microbiota and thyroid neoplasms. Methods: We procured data from the Mibiogen database encompassing 211 distinct gut microbiota taxa, alongside extensive genome-wide association studies (GWAS) summary data for differentiated thyroid carcinoma (DTC). Our principal analytical approach involved the application of the Inverse-Variance Weighted method (IVW) within the framework of Mendelian randomization. Simultaneously, we conducted sensitivity analyses to assess result heterogeneity, horizontal pleiotropy, and outcome stability. Results: IVW analysis revealed a du

SUBMITTER: Quan Z 

PROVIDER: S-EPMC10753834 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature