Causal effect of gut microbiota on Gastroduodenal ulcer: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Gastroduodenal ulcers are associated with Helicobacter pylori infection and the use of nonsteroidal anti-inflammatory drugs (NSAIDs). However, the causal relationship between gastroduodenal ulcers and gut microbiota, especially specific gut microbiota, remains unclear.

Methods

We conducted an analysis of published data on the gut microbiota and Gastroduodenal ulcer using genome-wide association studies (GWAS). Two-sample Mendelian randomization (MR) analysis was performed to determine the causal relationship between gut microbiota and Gastroduodenal ulcer. Sensitivity, heterogeneity, and pleiotropy analyses were conducted to confirm the accuracy of the research findings.

Results

Our study showed that the abundance of Enterobacteriaceae, But

SUBMITTER: Zhang J 

PROVIDER: S-EPMC10753992 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature