Elevated serum thyrotropin levels and endothelial dysfunction in a prospective hemodialysis cohort.

ABSTRACT:

Introduction

Thyroid dysfunction is a highly prevalent yet under-recognized complication in hemodialysis patients. In the general population, hypothyroidism has been associated with endothelial dysfunction due to impaired vasodilator synthesis and activity. Little is known about the association of serum thyrotropin (TSH), the most sensitive and specific single biochemical metric of thyroid function, with endothelial function in hemodialysis patients.

Methods

In a secondary analysis of 99 patients from the Anti-inflammatory and anti-oxidative nutrition in hypoalbuminemic dialysis patients (AIONID) trial, we examined measurements of serum TSH and endothelial function ascertained by fingertip digital thermal monitoring (DTM), a novel method used to measure micro-vascular reacti

SUBMITTER: You AS 

PROVIDER: S-EPMC10753993 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature