Lipidomic profiling in the Strong Heart Study identified American Indians at risk of chronic kidney disease.

ABSTRACT: Dyslipidemia associates with and usually precedes the onset of chronic kidney disease (CKD), but a comprehensive assessment of molecular lipid species associated with risk of CKD is lacking. Here, we sought to identify fasting plasma lipids associated with risk of CKD among American Indians in the Strong Heart Family Study, a large-scale community-dwelling of individuals, followed by replication in Mexican Americans from the San Antonio Family Heart Study and Caucasians from the Australian Diabetes, Obesity and Lifestyle Study. We also performed repeated measurement analysis to examine the temporal relationship between the change in the lipidome and change in kidney function between baseline and follow-up of about five years apart. Network analysis was conducted to identify differential li

SUBMITTER: Zeng W 

PROVIDER: S-EPMC10753995 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature