Prognostic Prediction of Genotype vs Phenotype in Genetic Cardiomyopathies.

ABSTRACT:

Background

Diverse genetic backgrounds often lead to phenotypic heterogeneity in cardiomyopathies (CMPs). Previous genotype-phenotype studies have primarily focused on the analysis of a single phenotype, and the diagnostic and prognostic features of the CMP genotype across different phenotypic expressions remain poorly understood.

Objectives

We sought to define differences in outcome prediction when stratifying patients based on phenotype at presentation compared with genotype in a large cohort of patients with CMPs and positive genetic testing.

Methods

Dilated cardiomyopathy (DCM), arrhythmogenic right ventricular cardiomyopathy, left-dominant arrhythmogenic cardiomyopathy, and biventricular arrhythmogenic cardiomyopathy were examined in this study. A total of 281 pa

SUBMITTER: Paldino A 

PROVIDER: S-EPMC10754019 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature