Multi-Functional Small Molecule Alleviates Fracture Pain and Promotes Bone Healing.

ABSTRACT: Bone injuries such as fractures are one major cause of morbidities worldwide. A considerable number of fractures suffer from delayed healing, and the unresolved acute pain may transition to chronic and maladaptive pain. Current management of pain involves treatment with NSAIDs and opioids with substantial adverse effects. Herein, we tested the hypothesis that the purine molecule, adenosine, can simultaneously alleviate pain and promote healing in a mouse model of tibial fracture by targeting distinctive adenosine receptor subtypes in different cell populations. To achieve this, a biomaterial-assisted delivery of adenosine is utilized to localize and prolong its therapeutic effect at the injury site. The results demonstrate that local delivery of adenosine inhibited the nociceptive activity

SUBMITTER: Shih YV 

PROVIDER: S-EPMC10754086 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature