Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis.

ABSTRACT: Effective anti-cancer immune responses require activation of one or more naïve T cells. If the correct naïve T cell encounters its cognate antigen presented by an antigen presenting cell, then the T cell can activate and proliferate. Here, mathematical modeling is used to explore the possibility that immune activation in lymph nodes is a rate-limiting step in anti-cancer immunity and can affect response rates to immune checkpoint therapy. The model provides a mechanistic framework for optimizing cancer immunotherapy and developing testable solutions to unleash anti-tumor immune responses for more patients with cancer. The results show that antigen production rate and trafficking of naïve T cells into the lymph nodes are key parameters and that treatments designed to enhance tumor antigen p

SUBMITTER: Nikmaneshi MR 

PROVIDER: S-EPMC10754116 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature