Collecting duct renin regulates potassium homeostasis in mice.

ABSTRACT:

Aim

The kaliuretic action of the renin-angiotensin-aldosterone system (RAAS) is well established as highlighted by hyperkalemia side effect of RAAS inhibitors but such action is usually ascribed to systemic RAAS. The present study addresses the involvement of intrarenal RAAS in K⁺ homeostasis with emphasis on locally generated renin within the collecting duct (CD).

Methods

Wild-type (Floxed) and CD-specific deletion of renin (CD renin KO) mice were treated for 7 days with a high K⁺ (HK) diet to investigate the role of CD renin in kaliuresis regulation and further define the underlying mechanism with emphasis on analysis of intrarenal aldosterone biosynthesis.

Results

In floxed mice, renin levels were elevated in the renal medulla and urine follow

SUBMITTER: Xu C 

PROVIDER: S-EPMC10754139 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature