Complex molecule synthesis by electrocatalytic decarboxylative cross-coupling.

ABSTRACT: Modern retrosynthetic analysis in organic chemistry is based on the principle of polar relationships between functional groups to guide the design of synthetic routes¹. This method, termed polar retrosynthetic analysis, assigns partial positive (electrophilic) or negative (nucleophilic) charges to constituent functional groups in complex molecules followed by disconnecting bonds between opposing charges^2-4. Although this approach forms the basis of undergraduate curriculum in organic chemistry⁵ and strategic applications of most synthetic methods⁶, the implementation often requires a long list of ancillary considerations to mitigate chemoselectivity and oxidation state issues involving protecting groups and precise reaction choreography^3,4,7

SUBMITTER: Zhang B 

PROVIDER: S-EPMC10754231 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature