Evaluation of the Blood-Brain Barrier, Demyelination, and Neurodegeneration in Paramagnetic Rim Lesions in Multiple Sclerosis on 7 Tesla MRI.

ABSTRACT:

Background

Paramagnetic rim lesions (PRLs) are associated with chronic inflammation in multiple sclerosis (MS). 7-Tesla (7T) magnetic resonance imaging (MRI) can evaluate the integrity of the blood-brain barrier (BBB) in addition to the tissue myelination status and cell loss.

Purpose

To use MRI metrics to investigate underlying physiology and clinical importance of PRLs.

Study type

Prospective.

Subjects

Thirty-six participants (mean-age 47, 23 females, 13 males) of mixed MS subtypes.

Field strength/sequence

7T, MP2RAGE, MULTI-ECHO 3D-GRE, FLAIR.

Assessment

Lesion heterogeneity; longitudinal changes in lesion counts; comparison of T1, R2*, and χ; association between baseline lesion types and disease progression (2-3 annual MRI visits with addition

SUBMITTER: Choi S 

PROVIDER: S-EPMC10754232 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature