A pH-sensitive eosin-block copolymer delivers proteins intracellularly.

ABSTRACT: There is great interest in developing strategies to deliver proteins into the cytoplasm of cells. We report here a PEG-poly-eosin block copolymer (PEG-pEosin) that can encapsulate proteins and release them in active form under mildly acidic conditions. A PEG-pEosin formulation composed of Cre and the endosomolytic protein LLO efficiently performed gene editing in cells and in the brains of mice after an intracranial injection.

SUBMITTER: Reinhard S 

PROVIDER: S-EPMC10754351 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature