Cerebellar Volume and Disease Staging in Parkinson's Disease: An ENIGMA-PD Study.

ABSTRACT:

Background

Increasing evidence points to a pathophysiological role for the cerebellum in Parkinson's disease (PD). However, regional cerebellar changes associated with motor and non-motor functioning remain to be elucidated.

Objective

To quantify cross-sectional regional cerebellar lobule volumes using three dimensional T1-weighted anatomical brain magnetic resonance imaging from the global ENIGMA-PD working group.

Methods

Cerebellar parcellation was performed using a deep learning-based approach from 2487 people with PD and 1212 age and sex-matched controls across 22 sites. Linear mixed effects models compared total and regional cerebellar volume in people with PD at each Hoehn and Yahr (HY) disease stage, to an age- and sex- matched control group. Associations with

SUBMITTER: Kerestes R 

PROVIDER: S-EPMC10754393 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature