Impacts of angiotensin II on retinal artery changes in apolipoprotein E deficient mice.

ABSTRACT:

Aim

To investigate the impacts of angiotensin II (Ang II) on retinal artery changes in apolipoprotein E deficient (apoE^-/-) mice.

Methods

apoE^-/- male mice were infused by minipumps with Ang II at 1000 ng/kg·min (Ang II group) or saline (control group) for 28d. They were underwent ophthalmic fundus examination on day 0, 14, and 28 of infusion. Histopathologic examination, ribonucleic acid (RNA) sequencing and local Ang II measurement of retinas were conducted.

Results

Ophthalmic fundus examination showed Ang II infusion promoted the formation of retinal arterial aneurysm-like lesions on day 28. Optical coherence tomography revealed the ganglion cell and inner plexiform layer (GCIPL) thickness in the control group was significantly t

SUBMITTER: Meng LH 

PROVIDER: S-EPMC10754664 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature