Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.

ABSTRACT:

Background

Multiple modes of cell death occur during the development of sepsis. Among these patterns, cuproptosis has recently been identified as a regulated form of cell death. However, its impact on the onset and progression of sepsis remains unclear.

Method

We screened a dataset of gene expression profiles from patients with sepsis using the GEO database. Survival analysis was performed to analyze the relationship between cuproptosis-related genes (CRGs) and prognosis. Hub genes were identified through univariate Cox regression analysis. The diagnostic value of hub genes in sepsis was tested in both training sets (GSE65682) and validation sets (GSE134347). To examine the association between hub genes and immune cells, single-sample gene set enrichment analysis (ssGSEA) an

SUBMITTER: Sun Z 

PROVIDER: S-EPMC10754710 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature