The Potential Role of Probiotics in the Management of Osteoarthritis Pain: Current Status and Future Prospects.

ABSTRACT:

Purpose of review

This narrative review article comprehensively explains the pathophysiology of osteoarthritis (OA) pain perception, how the gut microbiota is correlated with it, possible molecular pathways involved in probiotics-mediated OA pain reduction, limitations in the current research approaches, and future perspectives.

Recent findings

The initiation and progression of OA, including the development of chronic pain, is intricately associated with activation of the innate immune system and subsequent inflammatory responses. Trauma, lifestyle (e.g., obesity and metabolic disease), and chronic antibiotic treatment can disrupt commensal homeostasis of the human microbiome, thereby affecting intestinal integrity and promoting leakage of bacterial endotoxins and metabolite

SUBMITTER: Rahman SO 

PROVIDER: S-EPMC10754743 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature