Genetic polymorphisms of purinergic P2Y₂ receptor were associated with the susceptibility to essential hypertension in Chinese postmenopausal women.

ABSTRACT: Hypertension has become a prominent public health concern. Essential hypertension (EH) is a polygenic disorder caused by multiple susceptibility genes. It has been previously shown that the purinergic P2Y₂ receptor (P2Y₂R) regulates blood pressure; however, whether P2Y₂R genetic polymorphisms correlate with EH has not been investigated in Chinese. Our study included 500 EH cases and 504 controls who are Chinese postmenopausal women. We used allele-specific polymerase chain reaction (ASPCR) to genotype five single-nucleotide polymorphism (SNPs) in the P2Y₂R gene, i.e., rs4944831, rs12366239, rs1783596, rs4382936, and rs10898909. We assessed the association of P2Y₂R genetic polymorphisms with EH susceptibility. The results demonstrated t

SUBMITTER: Li A 

PROVIDER: S-EPMC10754786 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature