Adenosine A₁ receptor antagonist-induced facilitation of postsynaptic AMPA currents in pyramidal neurons of the rat hippocampal CA2 area.

ABSTRACT: Adenosine A₁ receptors (A₁R) are widely expressed in hippocampal pyramidal neurons and their presynaptic terminals. It is well known that endogenous adenosine regulates hippocampal function through the activation of A₁R in hippocampal pyramidal neurons and has been reported that blockade of A₁R induces stronger potentiation of excitatory synaptic transmission in CA2 pyramidal neurons than in CA1 pyramidal neurons. This strong potentiation of CA2 neurons is thought to be caused by the specific modulation of excitatory synaptic transmission through postsynaptic A₁R. However, the direct effects of A₁R on postsynaptic AMPA channels remain unknown because of the technical difficulties of patch-clamp recording from mature hippocam

SUBMITTER: Kawamura M 

PROVIDER: S-EPMC10754797 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature